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1, 2, 3 Treatment regimens containing high-dose melphalan (L-PAM) supported by stem cell transplant (SCT) increased response rates and progression-free survival compared with conventional therapy
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When paracetamol is also taken, it can lead to a buildup of an acid called 5-oxoproline in the blood
In contrast, it was not possible to estimate the IC50 value for primary human dermal fibroblasts (HDFs), as cell viability remained above 50% even at the highest concentration tested (50 M) after 24 h of treatment (Figure 1)
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