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At the same time, payer policies often require discontinuation of GLP-1 therapy when a patients BMI drops below a set threshold, inadvertently triggering a frustrating cycle of weight loss and regainthe so-called yo-yo effect. This not only impacts ongoing adherence and persistence but also undermines the long-term cost-effectiveness of these therapies for healthcare systems

Semaglutide may lead to common gastrointestinal side effects like vomiting, nausea, diarrhea, and constipation

These agents act more specifically, which lowers side effects and improves patient outcomes

it works in tandem with immune signals, metabolic hormones, and neurotransmitters like GABA, so its harmony matters for both short-term reactions and chronic health