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The frequency depends on your individual health needs and your doctors recommendation

doi:10.2337/db15-1255 17

Rare cases of intestinal obstruction have been reported with some agents

Abbreviations AcBut: 4-(4-acetylphenoxy)butanoic acid ADC: Antibody-drug conjugate ALL: Acute lymphoblastic leukemia AML: Acute myeloid leukemia BTG: Bacterial transglutaminase CLL: Chronic lymphocytic leukemia CM: Cyclization module CRC: Colorectal cancer DAR: Drug-antibody ratio DLBCL: Diffuse large B-cell lymphoma DM1: N 2 -Deacetyl-N 2 -(3-mercapto-1-oxopropyl)maytansine DM4: N 2 -Deacetyl-N 2 -(4-mercapto-4-methyl-1-oxopentyl)maytansine DUBA: Duocarmycin hydroxybenzamide azaindole FGE: Formylglycine generating enzyme mc: Maleimidocaproyl mcc: Maleimidomethyl cyclohexane-1-carboxylate, linked to cysteine of mAb MCC: Maleimidomethyl cyclohexane-1-carboxylate, linked to thiol of cytotoxin MDR: Multidrug resistance MM: Multiple myeloma MMAE: Monomethyl auristatin E MMAF: Monomethyl auristatin F NHL: Non-Hodgkin lymphoma NHS: N-hydroxy succinimide nnAA: Non-natural amino acid NSCLC: Non small-cell lung carcinoma PABC: Para-aminobenzyloxycarbonyl PBD: Pyrrolo[2,1-c][1,4]benzodiazepine RCC: Renal cell carcinoma SC: Squamous cell SCCHN: Squamous cell carcinoma of the head and neck SPDB: N-succinimidyl-4-(2-pyridyldithio)butanoate sulfo-SPDB: N-succinimidyl-4-(2-pyridyldithio)-2-sulfo butanoate va: Valine-alanine vc: Valine-citrulline References Schwartz RS

The pen should be discarded 56 days after starting use, even if there is some medication remaining