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Since oncometabolites are characteristic of tumor development and progression, identifying their differential levels in diverse biological samples compared to healthy individuals could be an interesting approach as novel prostate cancer biomarkers

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The complexity of the system is illustrated by findings that systemic salicylate-induced hyperactivity in the IC depends on nitric oxide signaling within that structure, which is known to mediate NMDA receptor signaling, indicating that interventions could target points in the signaling cascade upstream or downstream of the receptor itself (Olthof et al., 2022)