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Two further classes of enzymes which contribute to superoxide production are NADPH oxidases of which several isoforms are present in RBC (George et al., 2013) and endothelial NO synthase which is present in human and mouse RBC (Kleinbongard et al., 2006) and produces O 2 when L-arginine levels are low (Mihov et al., 2009)
This work was financially supported by grants from the Research Council of Finland (grant 315351 to PR, grant 266621 to HR, grant 321564 to VT, and grant 333284 to RK), the Sigrid Juslius Foundation (to PR, HR, VT, and RK), the Finnish Cultural Foundation (to PR and LP), Drug Research Doctoral Programme (to AS), the Finnish Foundation for Cardiovascular Research (to LP, HR, VT, RK, and PR), the Instrumentarium Science Foundation (to AS), and the National Institutes of Health (grant GM-104080 to MC)
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