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These factors can exacerbate disease severity, leading to increased morbidity and a reduced quality of life 13

10.1080/14756360701626223 48 GulcinI

Managing injection site reactions: Allow the pen to reach room temperature before injection if preferred for comfort Rotate injection sites systematically (abdomen, thigh, upper arm) Avoid injecting into areas with existing bruising, redness, or tenderness Apply gentle pressure (not rubbing) with clean gauze after injection Use proper injection techniqueinsert the needle at 90 degrees to the skin Avoid injecting through clothing When to seek medical advice: Contact your GP or healthcare provider if you experience severe pain, spreading redness, warmth suggesting infection, persistent swelling beyond 48 hours, or signs of an allergic reaction

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Lilly submitted tirzepatide for the treatment of HFpEF and obesity to the U.S