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This is most relevant for weight-based peptides like kisspeptin (dosed in mcg/kg) and less relevant for receptor-saturating peptides like BPC-157, where tissue concentration at the injury site matters more than total body distribution

HaCaT keratinocytes have also been proven to be good candidates for assessing skin irritancy and toxicity in conventional monolayer assays measuring using MTT reduction as the viability endpoint 21

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Although the serum half-life of lomustine ranges from 16 hours to 2 days, on the basis of our measurements of lung tissue GSR activity, its effect on GSR appears to last at least 72 hours after the first injection (Figure E5C)

Data or Concepts to Include: FDA cosmetics are regulated differently from approved drugs