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Although the prognosis of patients with advanced HCC remains poor, significant progress has been made with recent advances in drug development, particularly with the introduction of effective treatments such as atezolizumab plus bevacizumab or durvalumab plus tremelimumab

Social isolation stress can trigger these inflammatory pathways, leading to increased levels of IL-1, IL-6, and TNF-

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18 , 29 , 30 , 31 , 32 , 33 , 34 This is called mixed pathology dementia or simply mixed dementia