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They also found that ROSE-010 was most effective in patients with constipation-dominant IBS (IBS-C) and mixed IBS, with significantly less pain relief observed in patients with diarrhea-dominant or unspecified IBS [62]

Substances that are absorbed through the buccal route go directly into the systemic circulation and this eliminates disadvantages imposed by oral intake, such as the decreased ability of GSH to pass through the gastrointestinal tract as an intact molecule