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Whereas, M1 microglia release inflammatory mediators such as ROS, MMP-9 and pro-inflammatory cytokines such as TNF, IL-6 and IL-1.The balance between these different microglial phenotypic states promotes inflammation or tissue repair and influences the progression of neuroinflammatory disorders (Guedes et al., 2014)

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42:51-55 (2004) Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM

2020;18:4548 Honma K, Kohsaka M, Fukuda N, Morita N, Honma S