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The anti-inflammatory factor PGE 2 is key in inhibiting innate immune cells

109 The Nrf2 coordinates the basal and stress-inducible activation of the glutamate-cysteine ligase complex 110 and regulates the transcription of glutathione peroxidase 2 and glutathione S-transferases

doi: 10.26355/eurrev_201804_14749 206 PekalaJPatkowska-SokoaBBodkowskiRJamrozDNowakowskiPLochyskiSet al

Inflammation releases harmful proteins and reactive oxygen species (ROS), which may attack healthy tissues and lead to problems like: Blood Flow Issues: Blood is redirected to injury sites, reducing circulation to other areas, like the gut

INTRODUCTION Glutathione (GSH), the major intracellular thiol compound, is a ubiquitous tripeptide produced by most mammalian cells and it is the main mechanism of antioxidant defense against reactive oxygen species (ROS) and electrophiles