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129 Specially, studies also found that IDH1 is significantly downregulated in clear cell renal cell carcinoma (ccRCC) compared with normal kidney cells, suggesting that IDH1 may function as a candidate tumor suppressor for ccRCC

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Rare but serious side effects ( 10%), including but not limited to nausea, constipation or diarrhea, loss of appetite/feeling of fullness, and acid reflux