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Tirzepatide has demonstrated approximately 11.917.8% greater weight loss than placebo over 72 weeks, semaglutide about 12.4% greater weight loss over 68 weeks, and liraglutide around 8.0% weight reduction compared with placebo over 56 weeks

This leads to the secretion of IFN- and an upregulation of NKG2D ligands in the hair follicle, which can expose hair follicle-associated autoantigens and trigger an autoimmune response in alopecia areata

Reduced substance use and cravings: In a 2025 randomized trial, adults with alcohol use disorder who took low-dose semaglutide significantly reduced drinking and cravings compared with placebo

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