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Many medications, particularly biologics, may not work as well in patients carrying extra weight

DOria R, Schipani R, Leonardini A, Natalicchio A, Perrini S, Cignarelli A, et al

Sci Rep 13(1) Meloni AR, Deyoung MB, Lowe C, Parkes DG (2013) GLP-1 receptor activated insulin secretion from pancreatic -cells: mechanism and glucose dependence

The final concentration of 25 M FOXO4-DRI was added to the cells in a DMEM containing 2% FBS or 10% FBS

The daily administration of pasteurized bacteria over 3 months was found to be safe, well-tolerated, and resulted in improved insulin sensitivity and lipid profiles among the treated patients