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While tirzepatide established superiority over semaglutide in the SURMOUNT-5 trialachieving 20.2% weight loss vs 13.7%indirect network meta-analyses suggest that retatrutide will likely surpass tirzepatide in both absolute and percentage weight reduction

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While this isnt among the most common side effects, changes in blood sugar, immune response, or the vaginal microbiome may make some people more prone to symptoms like itching, burning, or unusual discharge