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[PMC free article: PMC3770071] [PubMed: 23434634] 771
Native GLP-1 has been infused by the subcutaneous route (4.8 pmol/kg/min) using a portable insulin pump in a non-randomized study of subjects with type 2 diabetes over the age of 40 (mean age 55) with mean initial HbA1c of about 9%, and mean fasting glucose ~14 mM
However, efficacy and tolerability depend on individual factors: baseline metabolic health, genetic variants in GLP-1R and GIPR expression, and adherence to dosing schedules
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![PDF] Safety and Metabolism of AOD9604, a Novel Nutraceutical Ingredient for Improved Metabolic Health](https://figures.semanticscholar.org/3dfd33b87b7a620653288e23e2a1afe5b3bdaab3/2-Table1-1.png)
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