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Novel biased GLP1 agonists described in the preclinical literature The first bespoke biased GLP1 agonist to be reported, P5, was obtained through an innovative strategy involving expression of single peptide sequences from an exendin4derived combinatorial peptide library, with peptides anchored to the cell surface via a flexible linker that allows autocrine activation of GLP1 receptors expressed in the same cell (Zhang et al., 2015)

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SLC7A11 is a superior determinant of APR-246 (Eprenetapopt) response than TP53 mutation status

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