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In our analysis of downregulated proteins, we observed a significant suppression of metabolic activities, particularly catabolic metabolism, and transport activities in gallstone bile

According to the World Health Organization, around 422 million people worldwide have diabetes, and 1.5 million deaths are directly attributed to diabetes each year

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484 Obeticholic acid is a bile acid derivative that activates FXR, which can ameliorate insulin sensitivity and decrease the expression of markers of liver fibrosis and inflammation in NAFLD and T2DM patients

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