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A structured eating plan can significantly improve outcomes

Metformin primarily reduces hepatic glucose production and improves peripheral insulin sensitivity, while tirzepatide enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes satiety

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Adjunct therapy with glucagon-like peptide 1 receptor agonists could offer benefits in this population of patients by preserving -cell mass and function while also contributing to cardiorenal risk mitigation

Injectable protocols vary by peptide and dose but typically require monitored cycles and periodic reassessment