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Some drugs block DAOan enzyme in the gut that breaks down histamine Many patients prefer natural treatments May have benefits beyond mast cell stabilisation Disadvantages of Using Natural Stabilizers for Mast Cell Activation Syndrome Supplements are bioactive compounds that may have unacceptable effects They may interfere with known medications They still have to be processed through the same liver detoxification enzymes as pharmaceuticals and thus may have unacceptable side effects Supplements may also contain excipients that produce unacceptable side effects Many of my patients find that these natural treatments are sufficient when it comes to treating their MCAS