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While this research suggests these drugs may be effective in promoting weight loss, once someone stops taking these medications, they tend to regain all of the lost weight

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Payers hesitation to cover GLP-1s for weight loss is also fueled by employer plan sponsor concerns about up-front costs of the drugs

Despite the limited expression of GLP-1 receptors in the cardiac tissue, they tend to enhance the myocardial function through multiple mechanisms, including optimizing the coronary vascular smooth muscle cells, and endothelial function of the coronary microvasculature and the peripheral vessels as well, in addition to improving blood glucose control and providing alternative energy substrates like ketones and lactate

Pharmaceutical GLP-1 agonistssuch as semaglutidehave become popular, but they are synthetic, require prescriptions, and may carry side effects with long-term use