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More than 90% of dietary TRP is metabolized via the KP, primarily in the liver [171], generating circulating KYN that readily crosses the BBB, whereas downstream metabolites such as KYNA, QA, and 3-HAA remain largely trapped within the CNS once synthesized [20]

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8.7 Individual difference factors modulating diet-depression associations 8.7.1 Age: shaping diet-induced depression progression Age affects the speed and severity of diet-induced depression by altering gut microbiota diversity, nutrient metabolism capacity, and neuroplasticityresulting in distinct risk profiles across life stages