Importantly, most researchers now believe the therapeutic effects of MSCs occur primarily through paracrine signaling , meaning the cells release biologically active substances that influence surrounding tissues rather than directly replacing cells
2008 Sep Sindhu Kashyap, Poorvikha Gowda, Roshini M Pasanna, Ambily Sivadas, Harshpal S Sachdev, Anura V Kurpad, Sarita Devi
53 Additionally, its effects on vascular tone and platelet function may increase bleeding risk, warranting caution in patients with bleeding disorders or those on blood thinners
Furthermore, such studies should carefully consider factors like age, sex, genetic background, and pre-existing health conditions, as these variables can significantly influence individual responses to hormetins
David Putrino from the Icahn School of Medicine at Mount Sinai