Category 2 substances also have sufficient supporting information, but the FDA has identified significant safety risks
Keatings lab is also designing peptides that could interfere with other relatives of Mcl-1, including one called Bfl-1, which has been less studied than the other members of the family but is also involved in blocking apoptosis
Tirzepatide has been associated with modest increases in resting heart rate (mean increase of 24 bpm in clinical trials), though the mechanism is unclear
doi: 10.1023/a:1008211226339
1 These include imipramine (Tofranil), midodrine (ProAmatine), chlorpheniramine (Chlor-Trimeton), brompheniramine (Veltane), ephedrine (Akovaz), pseudoephedrine (Sudafed), and phenylephrine (Vazculep)