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Start your intake What is GLP-1 and How Does Your Body Make It GLP-1 is an incretin hormone released by intestinal L-cells in response to nutrient intake, particularly glucose and amino acids

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Interestingly, in people with type 2 diabetes mellitus, who often exhibit glomerular hyperfiltration, GLP-1 receptor agonists stabilize or modestly reduce eGFR, an effect reminiscent of the initial declines observed with RAAS and SGLT2 inhibitors [64]

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Tirzepatide treatment was not associated with excess cardiovascular risk (54, 74)