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J Obstet Gynaecol Can

Additional IGF-1 is generated within target tissues, making it what appears to be both an endocrine and an autocrine/paracrine hormone

It plays a role in the mechanical conduction of blood flow shear force and can prevent endothelial cell dysfunction [9, 31]

Pro-inflammatory cytokines, including TNF-, IL-1, IL-6, IL-7, IL-15, IL-17, IL-18, IL-23, interferon (IFN)-, granulocyte-macrophage colony-stimulating factor (GM-CSF) have been found to govern inflammation in RA occurrence