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These conservative strategies can alleviate pain symptoms, but they cannot terminate the progression of cartilage deterioration and repair cartilage defects

These therapies are redefining chronic health condition management by offering new strategies for weight management and metabolic health

IBD is a chronic relapsing-remitting inflammatory condition encompassing ulcerative colitis (UC) and Crohns disease (CD), affecting approximately 6.8 million patients globally in 2017

Immunohistochemical staining for Nrf2, NQO1, and HO-1 expression on knee joint histological sections demonstrated that metformin administration significantly increased the numbers of Nrf2, NQO1, and HO-1-positive chondrocytes compared to those in OA group (Fig

Shimoyoshi S, Takemoto D, Ono Y, Kitagawa Y, Shibata H, Tomono S, et al