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Native IGF-1 (mecasermin) has been through the full regulatory pipeline: dose-ranging studies, controlled trials in the target population, characterized pharmacokinetics, a defined adverse-event profile, and ongoing post-marketing surveillance

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More recently, in 2010, uricase enzymes like Pegloticase and Rasburicase were approved for the management of persistent arthritis in patients with comorbidities and joint deformities

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