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However, because of individual differences in absorption and metabolism, the dose required to achieve complete, around-the-clock control varies from patient to patient

Previous studies suggest that the peroxidation of polyunsaturated fatty acids in phospholipids by lipoxygenases (ALOX) is particularly important for ferroptosis [65, 66]

Natural compounds such as resveratrol and pterostilbene have shown inhibition of ferroptosis in cardiomyocytes via the SIRT1/p53 and SIRT1/Glycogen Synthase Kinase-3 (GSK-3)/GPX4 signaling pathways, improving cardiac function and reducing cardiac remodeling in heart failure models (Zhang et al., 2023b

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