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After 24 weeks of treatment, the serum and urine measurements and physical examination carried out at baseline will be performed again (period 3) (Fig

Reduced body weight was observed in the offspring at greater than or equal to 30 mg/kg/day (approximately 4-times the 25 mg maximum clinical dose)

Consequently, on top of the beneficial effect of weight loss caused by GLP-1 analogues these drugs also cause a substantial reduction of the glycemic load (GL = carbohydrate intake X Glycemic index), which per se reduces hyperinsulinemia and causes weight loss [22], reduce diabetes risk [23], inflammation [24], and cardiovascular risk [25]

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