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Under hypoxia, CHCHD2 activates the transcription of itself and COX4I2 , which encodes cIV subunit-4 isoform 2 (COX IV-2) ( CHCHD2 show reduced cIV activity in addition to cI deficiency (Lee et al., 2018)

2024;15 [cited 2025 Aug 10]

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When combined with a calorie-controlled diet and consistent training, this may support small improvements in body composition

83 Another such study that included 3,489 individuals over age 50 found vitamin D deficiency was correlated generally with hearing impairment and specifically with sensorineural hearing loss