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It has a very short elimination half-life of 1.5-2 hrs

For each of the known and possible risk factors for metformin-associated lactic acidosis, recommendations to reduce the risk of and manage metformin-associated lactic acidosis are provided below: Renal Impairment The postmarketing metformin-associated lactic acidosis cases primarily occurred in patients with significant renal impairment

that often translates into feeling full on less food, fewer cravings between meals, and smoother post meal blood sugar curves, which can lead to gradual fat loss when combined with modest calorie reduction