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A synbiotic can improve gut-microbiota composition, increase the production of beneficial metabolites such as SCFAs, and reduce systemic inflammation, all factors involved in CVD progression [111114]

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The authors reported statistically significant mean reductions in body weight from baseline across the retatrutide dose groups relative to placebo, with gastrointestinal adverse events the most frequently reported findings, consistent with the incretin-agonist class

Dietary response: The medication reduces appetite, but you still choose what to eat