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Moreover, PGC-1 also interacts with PPAR, the master regulator of FAO to upregulate the expression of FAO-related genes, such as CPT1, SLC25A20 and CPT2 (Tachibana et al., 2009

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A recent cohort study found that semaglutide was associated with significant weight loss outcomes compared to placebo, leading to reductions up to 15 percent body weight among those patients taking prescription doses of semaglutide

Therefore, specific dose adjustment may not be warranted in subjects with RI

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