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An example of when lowering GCLM/GCLC causes decreased GSH is the expression of the HIV-Tat protein, which suppresses GCLM expression (Choi et al., 2000)

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Not only that but you end up with increased amounts of oxidants which have been linked to accelerate the ageing process

The risk of asthma is higher in children exposed to acetaminophen during pregnancy, and that risk is exacerbated by maternal genetic variants related to acetaminophen detoxification.[ref] Genetic interactions with acetaminophen: With multiple routes of detoxification, most people can take acetaminophen without liver damage

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