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Structured exercise and high protein intake can significantly reduce the lean mass deficit

Others prefer Zepbound if appetite control improves adherence despite stronger early effects

Currently approved weight management pharmacotherapy in the UK includes: Semaglutide (Wegovy) a GLP-1 receptor agonist approved by the MHRA for chronic weight management in adults, subject to NICE Technology Appraisal eligibility criteria [3] [5] Tirzepatide (Mounjaro) a dual GIP/GLP-1 receptor agonist approved by the MHRA for the treatment of type 2 diabetes

The real figure is impossible to quantify but is likely many magnitudes higher

For management strategies, see our complete side effects guide