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Pharmacokinetic Parameters Clinical Uses Monotherapy in T2DM when diet and exercise alone are insufficient Combination therapy with metformin, sulfonylureas, or insulin Particularly useful in patients at risk of hypoglycemia or needing once-daily dosing Adverse Effects Typically well tolerated Possible nasopharyngitis, headache, upper respiratory symptoms Rare: pancreatitis, hypersensitivity reactions Low risk of hypoglycemia when used alone Comparative Analysis MCQs Januvia inhibits which enzyme

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