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Additionally, ethics related to animal welfare, and changes in the legislation in several geographies have motivated the development of more human-relevant tools and approaches that do not rely on the generation of new animal data to test chemicals (Brescia et al., 2023

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It enhances fat metabolism, spares glycogen for later use, and increases muscle contractility

To that end, chemicals from the list generated herein are being selected and implemented in pre-validation studies of hPPAR and hPPAR transactivation assays (59) and hMSC cells in the GOLIATH project