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Similarly, the aging rats untreated with IGF1 exhibit a significant mitochondrial dysfunction, including reduced activity of ATPase and complex IV (Garcia-Fernandez et al., 2008
Its deficiency is manifested through changes in the number and morphology of erythrocytes, leucocytes and platelets, and by neurological alterations owed to the progressive demineralisation of the nervous system (a consequence of defective myelin synthesis)
Sources and further reading Wilding JPH, et al
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