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147 Leptin binds to the leptin receptor (LepRb) and activates JAK2/STAT3 pathway to decrease body weight and normalizes blood glucose concentration, meanwhile, JAK2 stimulates the phosphorylation of insulin receptor substrate (IRS1/2), then activates PI3K/Akt pathway and directly affect insulin action

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Science 261:466469 Keller J, Beglinger C, Holst JJ, Andresen V, Layer P (2009) Mechanisms of gastric emptying disturbances in chronic and acute inflammation of the distal gastrointestinal tract

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