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Furthermore, as patients lose weight, the absolute caloric deficit created by the same dietary intake diminisheswhat constituted a 500-calorie daily deficit at a higher weight may only represent a 300-calorie deficit after significant weight loss

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In rat pups and young piglets, dietary deprivation of glutamine has been reported to diminish intestinal integrity, through breakdown of epithelial junctions and shortening of microvilli (119, 120)