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This milestone for the Danish pharmaceutical giant was not unexpected

J Physiol 2005;569:76172 26

In vivo studies have shown that microneedle-mediated delivery of semaglutide analogs leads to comparable or improved pharmacokinetics versus subcutaneous injections, with potential for once-weekly or biweekly dosing schedules [42]

This single step reduces injection discomfort more than almost any other technique adjustment

In contrast, infusions of native GLP-1 at physiological doses (0.75 pmolkg 1 min 1 ) show a preferential effect on the visual perception of food, without significant alterations in palatability parameters (176)