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Setmelanotide AUC and Cmax increased proportionally following multiple-dose subcutaneous administration in the proposed dose range (1-3 mg)

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7 Huntingtons disease is an autosomal dominant disorder that is caused by the expansion of CAG trinucleotide repeats in the huntingtin gene 6

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This is because orforglipron is a small molecule absorbed through passive diffusion in the small intestine, rather than a peptide requiring the SNAC absorption enhancer and stomach-specific absorption conditions needed by Rybelsus