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When oxidative stress (e.g., H 2 O 2 treatment) leads to an increase in mitochondrial membrane permeability, mt-dsRNA leaks into the cytoplasm through voltage-dependent anion channels (VDAC) to form a pool of stress granule-associated free dsRNA [166]

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Although carnitine supplementation has been widely used to prevent and treat fatty liver toxicity caused by VPA, recent studies have shown that carnitine supplementation has a minimal therapeutic effect in patients with acute toxicity caused by VPA( 4.2 Protective role of feno by regulation of ACs-related gene expression in VPA-induced abnormal liver function Peroxisome proliferator-activated receptors (PPARs) are involved in various lipid and glucose metabolic pathways (Yang et al., 2016