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NRF2 expression was markedly decreased in NSC-34 motor neuron cells transfected with the human SOD1 G93A gene, leading to significantly increased levels of MDA, GSH, and ROS, along with reduced expression of SLC7A11 and GPX4

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Such observations have also been seen in human liver cirrhosis [20]

doi: 10.1007/s13224-019-01251-1 87 CalogeroAGulloGLa VigneraSCondorelliRVaiarelliA