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Peer review Peer review information Nature Medicine thanks the anonymous reviewers for their contribution to the peer review of this work

Hypothesis: Thanks to a stronger weight loss, CagriSema should lead to a superior reduction of MACE compared to Semaglutide in SELECT (where Semaglutide reduced MACE by 20 %)

Anti-Inflammatory Properties : BPC 157 has demonstrated anti-inflammatory effects, which can help mitigate inflammation and promote recovery from various injuries 5

More recently, agents such as semaglutide and liraglutide have received FDA approval for obesity treatment in individuals without diabetes, expanding on previous indications [1]

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