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doi: 10.1016/j.molmet.2019.09.010 41 LiYHansotiaTYustaBRisFHalbanPADruckerDJ

In HFrEF, an issue remains that because GLP-1 RAs have been shown to modestly increase heart rate (2-3 beats per minute) owing to their chronotropic effects (see Mechanisms) (Sun et al., 2015), GLP-1 RA treatment in HFrEF may be problematic considering that, in line with the use of beta-blockers to ameliorate HFrEF (11, 12), heart rate elevations may result in a worse outcome (Ibrahim et al., 2019)

GSK3: glycogen synthase kinase-3 beta

Bruegger JJ, Smith BC, Wynia-Smith SL, Marletta MA

Los estudios en clulas y animales sugieren que los GLP-1 podran mejorar los resultados en este grupo