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Significant swelling, especially around eyes or lips

View Study [2]"A Synthetic ERR Agonist Alleviates Metabolic Syndrome" Billon C, Schoepke E, Avdagic A, et al., 2024 Finding: Mice with diet-induced obesity or genetic obesity showed impressive results: SLU-PP-332 increased energy expenditure, boosted fat burning, reduced fat mass, and improved insulin sensitivity

It is about your diagnosis, what you have already tried, and whether the basics have been properly done