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Carballo-Casla A et al

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The rhythmicity of melatonin secretion is not very pronounced in young babies, but it becomes more rhythmic over time, and factors such as artificial lighting and lack of sunlight exposure can disrupt this rhythmicity, making people somewhat arrhythmic or phase-shifted 2m6s

For accurate determination of insulin secretion, independent of varying hepatic insulin extraction, it may be useful to measure plasma levels of C-peptide, proinsulin's connecting peptide, which is not extracted in the human liver