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[2] [9] These effects are typically dose-dependent, most pronounced during dose escalation, and tend to diminish over time as patients develop tolerance

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Histopathological examination of endomyocardial biopsies from SUN-treated patients who developed heart failure revealed cardiomyocyte hypertrophy and mitochondrial abnormalities including swelling, membrane whorls, and effaced cristae [4, 6]

These practices are often incorporated into recovery-focused research models involving tissue repair and regeneration